A Randomized Clinical Trial of a Mixture of Probiotic Strains

Title : Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial

Importance : Oral intake of new probiotic formulations may improve the course of atopic dermatitis (AD) in a young population.

Objective : To determine whether a mixture of oral probiotics is safe and effective in the treatment of AD symptoms and to evaluate its influence on the use of topical steroids in a young population.

Design, Setting, and Participants : A 12-week randomized, double-blind, placebo-controlled intervention trial, from March to June 2016, at the outpatient hospital Centro Dermatológico Estético de Alicante, Alicante, Spain. Observers were blinded to patient groupings. Participants were children aged 4 to 17 years with moderate atopic dermatitis. The groups were stratified and block randomized according to sex, age, and age of onset. Patients were ineligible if they had used systemic immunosuppressive drugs in the previous 3 months or antibiotics in the previous 2 weeks or had a concomitant diagnosis of intestinal bowel disease or signs of bacterial infection.

Interventions : Twelve weeks with a daily capsule containing freeze-dried powder with 109 total colony-forming units of the probiotic strains Bifidobacterium lactis CECT 8145, B longum CECT 7347, and Lactobacillus casei CECT 9104 and maltodextrin as a carrier, or placebo (maltodextrin-only capsules).

Main Outcomes and Measures : SCORAD index score and days of topical steroid use were analyzed.

Results : Fifty children (26 [50%] female; mean [SD] age, 9.2 [3.7] years) participated. After 12 weeks of follow-up, the mean reduction in the SCORAD index in the probiotic group was 19.2 points greater than in the control group (mean difference, −19.2; 95% CI, −15.0 to −23.4). In relative terms, we observed a change of −83% (95% CI, −95% to −70%) in the probiotic group and −24% (95% CI, −36% to −11%) in the placebo group (P < .001). We found a significant reduction in the use of topical steroids to treat flares in the probiotic arm (161 of 2084 patient-days [7.7%]) compared with the control arm (220 of 2032 patient-days [10.8%]; odds ratio, 0.63; 95% CI, 0.51 to 0.78).

Conclusions and Relevance : The mixture of probiotics was effective in reducing SCORAD index and reducing the use of topical steroids in patients with moderate AD.

Trial Registration: clinicaltrials.gov Identifier: NCT02585986

Read the complete study at The Journal of the American Medical Association Network.

ProZema Probiotic

ProZema is a unique blend of three patented probiotic strains that reduce the symptoms of eczema and atopic dermatitis. It has been clinically proven to reduce the symptoms of eczema and atopic dermatitis in children aged 4-17 years old.

Probiotics

During the past few years, the association between the origin of atopic dermatitis and the disruption in the intestinal barrier function has been highlighted. There have also been recent analysis of the gut microbiota of patients with atopic dermatitis.

These show a reduction in the production of short-chain fatty acids that play an anti-inflammatory role. This reduction may create a pro-inflammatory state in the gut and a loss of barrier integrity.

A lower diversity of microbiota during the earliest infancy is also a suggested risk factor for atopic dermatitis. Together, these associations support the use of probiotics in atopic dermatitis treatments.

Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. They are a part of your microbiome and help balance the good and bad bacteria in your body.  The bacteria lactobacillus and bifidobacterium can be found in many parts of your body, including the gut. Probiotics can be safely consumed.

They are a part of your microbiome and help balance the good and bad bacteria in your body.  The bacteria lactobacillus and bifidobacterium can be found in many parts of your body, including the gut. Probiotics can be safely consumed.

ProZema is unique probiotic blend. It contains three patented strains:

  • Bifidobacterium lactis CECT 8145,
  • Bifidobacterium longum CECT 7347, and
  • Lactobacillus casei CECT 9104

This combination has been formulated with well-characterized strains. Bifidobacterium lactis CECT 8145 features antioxidant properties. Bifidobacterium longum CECT 7347 has anti-inflammatory characteristics. Lactobacillus casei CECT 9104 also features antioxidant properties and promotes microbiome diversity in the gut.

Convenient Powder Form

ProZema is available in powder form and can be mixed in liquids or sprinkled over food. ProZema fits into your and your child’s schedule as it can be taken with breakfast, lunch, or dinner. It has a neutral taste tasteless and is odourless, which makes it ideal for picky eaters and people sensitive to smells. Snip the sticks open and dissolve ProZema into a milk and cereal for easy ingestion.

Each box of ProZema probiotic supplement contains 30 individual sticks so you can keep track of the doses easily. For best results, use ProZema for the recommended 3 months.

Clinically Proven Results

ProZema has been clinically shown to reduce the symptoms of eczema and atopic dermatitis within 12 weeks. In the trial, patients were able to stop the use of corticosteroids after 6 weeks of taking ProZema.

The SCORAD index value measures the severity of atopic dermatitis. Higher index values mean severe cases, while lower index values mean mild cases.

A single-center, randomized, double-blind clinical research trial was carried out. In this trial, 96% of patients in the probiotic group improved their SCORAD index values. This means the severity of atopic dermatitis was reduced.

The reduction in severity was measured. In the probiotic group, patients displayed an 84% reduction in SCORAD index values. This means the SCORAD scores changed from higher to lower values.

In 91% of patients the symptoms of atopic dermatitis had cleared or almost cleared within 12 weeks.

ProZema is a natural treatment option for patients of eczema and atopic dermatitis. As an adjunct therapy, ProZema fits into curated treatment plans.

Find ProZema Probiotic near you now! ProZema Probiotic is widely available in pharmacies, drugstores, retailers, and online.